Rabbit anti-Human PLAA Polyclonal Antibody

The antibody against PLAA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03976A

Number

Cat.No	ADA-03976A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PLAA
Target Synonyms	DOA1; PLAP; PLA2P; NDMSBA; PLAA	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-549, HT-1080, Mouse brain	Application	ELISA, WB

Cat.No

ADA-03976A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PLAA

Target Synonyms

DOA1; PLAP; PLA2P; NDMSBA; PLAA

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-549, HT-1080, Mouse brain

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1).	Target Species	Human
Uniprot ID	Q9Y263	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1).

Target Species

Human

Uniprot ID

Q9Y263

Immunogen Sequence

Background Information

Uniprot Id

Q9Y263
Target Species

Human
Target Name

PLAA
Target Full Name

Phospholipase A-2-activating protein
Target Function

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Target Involvement

Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
Target Subcellular Location

Nucleus. Cytoplasm. Cell junction, synapse.
Target Protein Families

WD repeat PLAP family
Target Synonyms

DOA1; PLAP; PLA2P; NDMSBA; PLAA
Target Background

Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus.

Rabbit anti-Human PLAA Polyclonal Antibody

Specifications

Immunogen Information

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