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The antibody against PMAIP1 was raised in rabbit using the Full length fusion protein as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PMAIP1 was raised in rabbit using the Full length fusion protein as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$297.00
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/50.
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/50.2
| Cat.No | ADC-40642A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMAIP1 |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | 0.05% NaN3, 50% Glycerol, Rabbit IgG in pH7.3 PBS | Purification Method | Antigen affinity purified |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Full length fusion protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13794 |
Uniprot Id
Q13794
Target Species
Human
Target Name
PMAIP1
Target Full Name
Phorbol-12-myristate-13-acetate-induced protein 1
Target Function
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Target Subcellular Location
Mitochondrion.
Target Protein Families
PMAIP1 family
Target Tissue Specificity
Highly expressed in adult T-cell leukemia cell line.
Target Synonyms
Adult T cell leukemia derived PMA responsive; APR; APR_HUMAN; ATL-derived; Immediate early response protein APR; Immediate-early-response protein APR; NOXA; Phorbol 12 myristate 13 acetate induced protein 1; Phorbol-12-myristate-13-acetate-induced protein 1; PMA induced protein 1; PMA-induced protein 1; PMA-responsive gene; Pmaip1; Protein Noxa
Target Background
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state.
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