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The antibody against PTPN14 was raised in rabbit using the Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 protein (220-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against PTPN14 was raised in rabbit using the Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 protein (220-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-04100A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PTPN14 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 protein (220-351AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15678 |
Uniprot Id
Q15678
Target Species
Human
Target Name
PTPN14
Target Full Name
Tyrosine-protein phosphatase non-receptor type 14
Target Function
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Target Involvement
Choanal atresia and lymphedema (CHATLY)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Target Protein Families
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Target Tissue Specificity
Ubiquitous.
Target Research Area
Signal Transduction
Target Synonyms
Cytoskeletal associated protein tyrosine phosphatase; MGC126803; PEZ; Phosphatase with ezrin domain; Protein tyrosine phosphatase non receptor type 14; Protein tyrosine phosphatase pez; Protein-tyrosine phosphatase pez; PTN14_HUMAN; PTP 36; PTP36; PTPD 2; PTPN 14; PTPN14; Tyrosine protein phosphatase non receptor type 14; Tyrosine-protein phosphatase non-receptor type 14
Target Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
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