Rabbit anti-Human PUS1 Polyclonal Antibody

The antibody against PUS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 308-427 of human PUS1 (NP_079491.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01124A

Number

Cat.No	ADA-01124A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PUS1
Target Synonyms	MLASA1; PUS1	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	U-87MG	Application	ELISA, WB

Cat.No

ADA-01124A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PUS1

Target Synonyms

MLASA1; PUS1

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 308-427 of human PUS1 (NP_079491.2).	Target Species	Human
Immunogen Sequence	YAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD	Uniprot ID	Q9Y606

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 308-427 of human PUS1 (NP_079491.2).

Target Species

Human

Immunogen Sequence

YAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD

Uniprot ID

Q9Y606

Background Information

Uniprot Id

Q9Y606
Target Species

Human
Target Name

PUS1
Target Full Name

Pseudouridylate synthase 1 homolog
Target Function

Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA.
Target Involvement

Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1)
Target Subcellular Location

[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
Target Protein Families

TRNA pseudouridine synthase TruA family
Target Tissue Specificity

Widely expressed. High levels of expression found in brain and skeletal muscle.
Target Synonyms

A730013B20Rik; DOBI; MGC112655; MGC11268; MLASA; MLASA1; mPus1p; Pseudouridine synthase 1; Pseudouridylate synthase 1; PUS1; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA uridine isomerase I; tRNA-uridine isomerase I; TRUA_HUMAN
Target Background

This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.

Rabbit anti-Human PUS1 Polyclonal Antibody

Specifications

Immunogen Information

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