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The antibody against QPRT was raised in rabbit using the Recombinant Human Nicotinate-nucleotide pyrophosphorylase [carboxylating] protein (113-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against QPRT was raised in rabbit using the Recombinant Human Nicotinate-nucleotide pyrophosphorylase [carboxylating] protein (113-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-04105A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | QPRT |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Nicotinate-nucleotide pyrophosphorylase [carboxylating] protein (113-254AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15274 |
Uniprot Id
Q15274
Target Species
Human
Target Name
QPRT
Target Full Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Target Function
Involved in the catabolism of quinolinic acid (QA).
Target Protein Families
NadC/ModD family
Target Synonyms
NADC_HUMAN; Nicotinate nucleotide pyrophosphorylase (carboxylating); Nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; QPRT; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]; Quinolinate phosphoribosyltransferase
Target Background
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants.
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