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The antibody against RAPGEF4 was raised in rabbit using the Recombinant Human Rap guanine nucleotide exchange factor 4 protein (1-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RAPGEF4 was raised in rabbit using the Recombinant Human Rap guanine nucleotide exchange factor 4 protein (1-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using RAPGEF4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using RAPGEF4 Antibody at dilution of 1:1002
| Cat.No | ADC-16538A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RAPGEF4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Rap guanine nucleotide exchange factor 4 protein (1-210AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WZA2 |
Uniprot Id
Q8WZA2
Target Species
Human
Target Name
RAPGEF4
Target Full Name
Rap guanine nucleotide exchange factor 4
Target Function
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Target Tissue Specificity
Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
Target Synonyms
CAMP GEFII; cAMP regulated guanine nucleotide exchange factor II; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CAMPGEFII; CGEF 2; CGEF2; Epac 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Nbla00496; Putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAPGEF 4; Rapgef4; RPGF4_HUMAN
Target Background
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder.
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