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The antibody against SHOC2 was raised in rabbit using the Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SHOC2 was raised in rabbit using the Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human lung tissue using SHOC2 Antibody at dilution of 1:1002
| Cat.No | ADC-10022A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SHOC2 |
| Target Synonyms | KIAA0862 antibody; Leucine-rich repeat protein SHOC-2 antibody; Protein soc-2 homolog antibody; Protein Sur-8 homolog antibody; Ras-binding protein Sur-8 antibody; SHOC2 antibody; SHOC2_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UQ13 |
Uniprot Id
Q9UQ13
Target Species
Human
Target Name
SHOC2
Target Full Name
Leucine-rich repeat protein SHOC-2
Target Function
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Target Involvement
Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
SHOC2 family
Target Synonyms
KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein Sur-8 homolog; Ras-binding protein Sur-8; SHOC2; SHOC2_HUMAN
Target Background
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
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