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The antibody against SLC7A7 was raised in rabbit using the Recombinant Human Y+L amino acid transporter 1 protein (325-382AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SLC7A7 was raised in rabbit using the Recombinant Human Y+L amino acid transporter 1 protein (325-382AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using SLC7A7 Antibody at dilution of 1:1002
| Cat.No | ADC-17717A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SLC7A7 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Y+L amino acid transporter 1 protein (325-382AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UM01 |
Uniprot Id
Q9UM01
Target Species
Human
Target Name
SLC7A7
Target Full Name
Y+L amino acid transporter 1
Target Function
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
Target Involvement
Lysinuric protein intolerance (LPI)
Target Subcellular Location
Basolateral cell membrane; Multi-pass membrane protein.
Target Protein Families
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Target Tissue Specificity
Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret
Target Synonyms
LAT3; LPI; Monocyte amino acid permease 2; MOP-2; MOP2; SLC7A 7; Slc7a7; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 ; Solute carrier family 7 member 7; y(+)L type amino acid transporter 1; y(+)L-type amino acid transporter 1; Y+L amino acid transporter 1; y+LAT-1; Y+LAT1; YLAT1_HUMAN
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