Rabbit anti-Human SSTR3 Polyclonal Antibody

Uniprot Id

P32745

Target Species

Human

Target Name

SSTR3

Target Full Name

Somatostatin receptor type 3

Target Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Brain, pituitary and pancreas.

Target Synonyms

SSTR3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28

Target Background

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants.