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The antibody against SULF2 was raised in rabbit using the Recombinant Human Extracellular sulfatase Sulf-2 protein (463-660AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SULF2 was raised in rabbit using the Recombinant Human Extracellular sulfatase Sulf-2 protein (463-660AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human salivary gland tissue using SULF2 Antibody at dilution of 1:1002
| Cat.No | ADC-11796A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SULF2 |
| Target Synonyms | Extracellular sulfatase Sulf 2 antibody; Extracellular sulfatase Sulf-2 antibody; HSulf-2 antibody; HSulf2 antibody; Sulf2 antibody; SULF2_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Extracellular sulfatase Sulf-2 protein (463-660AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IWU5 |
Uniprot Id
Q8IWU5
Target Species
Human
Target Name
SULF2
Target Full Name
Extracellular sulfatase Sulf-2
Target Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Target Subcellular Location
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
Target Protein Families
Sulfatase family
Target Tissue Specificity
Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
Target Synonyms
Extracellular sulfatase Sulf 2; Extracellular sulfatase Sulf-2; HSulf-2; HSulf2; Sulf2; SULF2_HUMAN
Target Background
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).
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