Rabbit anti-Human TKTL1 Polyclonal Antibody

Uniprot Id

P51854

Target Species

Human

Target Name

TKTL1

Target Full Name

Transketolase-like protein 1

Target Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476).

Target Protein Families

Transketolase family

Target Tissue Specificity

Expressed in fetal and adult heart, brain, lung, liver, and kidney, and in adult placenta, skeletal muscle and pancreas. Up-regulated in various epithelial tumors.

Target Synonyms

TK 2; TK2; TKR; TKT 2; TKT2; TKTL1; TKTL1_HUMAN; Transketolase 2; Transketolase like 1; Transketolase like protein 1; Transketolase related protein; transketolase-like 1; Transketolase-like protein 1; Transketolase-related protein; Transketolase2

Target Background

The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene.