Rabbit anti-Human TRAPPC2 Polyclonal Antibody

Uniprot Id

P0DI81

Target Species

Human

Target Name

TRAPPC2

Target Full Name

Trafficking protein particle complex subunit 2

Target Function

Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Target Involvement

Spondyloepiphyseal dysplasia tarda (SEDT)

Target Subcellular Location

Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment. Nucleus. Cytoplasm.

Target Protein Families

TRAPP small subunits family, Sedlin subfamily

Target Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.

Target Synonyms

TRAPPC2; SEDL; Trafficking protein particle complex subunit 2; Sedlin

Target Background

The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene.