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The antibody against VAV1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human VAV1 around the phosphorylation site of tyrosine 174 (E-I-Y-E-D). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against VAV1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human VAV1 around the phosphorylation site of tyrosine 174 (E-I-Y-E-D). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
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Western blot analysis of extracts from Jurkat cells, using VAV1 (Ab-174) antibody.
Western blot analysis of extracts from JK cells (Lane 2), using VAV1 (Ab-174) antiobdy. The lane on the left is treated with synthesized peptide.2
| Cat.No | ADC-42570A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VAV1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human VAV1 around the phosphorylation site of tyrosine 174 (E-I-Y-E-D). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P15498 |
Uniprot Id
P15498
Target Species
Human
Target Name
VAV1
Target Full Name
Proto-oncogene vav
Target Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Target Tissue Specificity
Widely expressed in hematopoietic cells but not in other cell types.
Target Synonyms
Oncogene vav; p95Vav; Proto-oncogene vav; Protooncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; VAV_HUMAN; VAV1
Target Background
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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