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The antibody against lktA was raised in rabbit using the Recombinant Mannheimia haemolytica Leukotoxin protein (715-953AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against lktA was raised in rabbit using the Recombinant Mannheimia haemolytica Leukotoxin protein (715-953AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-50610A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | lktA |
| Target Synonyms | lktA antibody; Leukotoxin antibody; Lkt antibody | Form | Liquid |
| Species Reactivity | Mannheimia haemolytica | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Mannheimia haemolytica Leukotoxin protein (715-953AA) | Target Species | Mannheimia haemolytica |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P0C085 |
Uniprot Id
P0C085
Target Species
Mannheimia haemolytica
Target Name
LKTA
Target Function
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity.
Target Subcellular Location
Secreted. Host cell membrane; Multi-pass membrane protein.
Target Protein Families
RTX prokaryotic toxin (TC 1.C.11) family
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