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The antibody against DEFB126 was raised in rabbit using the Recombinant Pongo pygmaeus Beta-defensin 126 protein (21-63AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against DEFB126 was raised in rabbit using the Recombinant Pongo pygmaeus Beta-defensin 126 protein (21-63AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-44624A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DEFB126 |
| Target Synonyms | DEFB126Beta-defensin 126 antibody; Defensin antibody; beta 126 antibody | Form | Liquid |
| Species Reactivity | Pongo pygmaeus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Pongo pygmaeus Beta-defensin 126 protein (21-63AA) | Target Species | Pongo pygmaeus (Bornean orangutan) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A4H244 |
Uniprot Id
A4H244
Target Species
Pongo pygmaeus
Target Name
DEFB126
Target Function
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
Target Subcellular Location
Secreted.
Target Protein Families
Beta-defensin family
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