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The antibody against Ngf was raised in rabbit using the Recombinant Rat Beta-nerve growth factor protein (124-241AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Ngf was raised in rabbit using the Recombinant Rat Beta-nerve growth factor protein (124-241AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-51123A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NGF |
| Target Synonyms | Ngf antibody; Ngfb antibody; Beta-nerve growth factor antibody; Beta-NGF antibody | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Rat Beta-nerve growth factor protein (124-241AA) | Target Species | Rattus norvegicus (Rat) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P25427 |
Uniprot Id
P25427
Target Species
Rat
Target Name
NGF
Target Full Name
Beta-nerve growth factor
Target Function
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Target Subcellular Location
Secreted. Endosome lumen.
Target Protein Families
NGF-beta family
Target Tissue Specificity
Detected in the granule and pyramidal cell layer in the hippocampus.
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