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The antibody against VP40 was raised in rabbit using the Recombinant Reston ebolavirus Matrix protein VP40 protein (1-331AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against VP40 was raised in rabbit using the Recombinant Reston ebolavirus Matrix protein VP40 protein (1-331AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-19289A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VP40 |
| Target Synonyms | VP40Matrix protein VP40 antibody; Membrane-associated protein VP40 antibody | Form | Liquid |
| Species Reactivity | Reston ebolavirus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Reston ebolavirus Matrix protein VP40 protein (1-331AA) | Target Species | Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8JPX9 |
Uniprot Id
Q8JPX9
Target Species
Reston ebolavirus
Target Name
VP40
Target Function
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).
Target Subcellular Location
Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein.
Target Protein Families
Filoviridae matrix protein VP40 family
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