Rabbit anti-Human Neurofilament L Polyclonal Antibody

The antibody against Neurofilament L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L (NP_006149.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-12255A

Number

Cat.No	ADA-12255A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Neurofilament L
Target Synonyms	NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; Neurofilament L	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, 293T, Mouse brain, SH-SY5Y, U-251MG	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-12255A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Neurofilament L

Target Synonyms

NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; Neurofilament L

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, 293T, Mouse brain, SH-SY5Y, U-251MG

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L (NP_006149.2).	Target Species	Human
Immunogen Sequence	SSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVT	Uniprot ID	P07196

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L (NP_006149.2).

Target Species

Human

Immunogen Sequence

SSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVT

Uniprot ID

P07196

Background Information

Uniprot Id

P07196
Target Species

Human
Target Name

NEFL
Target Full Name

Neurofilament light polypeptide
Target Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Target Involvement

Charcot-Marie-Tooth disease 1F (CMT1F); Charcot-Marie-Tooth disease 2E (CMT2E)
Target Subcellular Location

Cell projection, axon. Cytoplasm, cytoskeleton.
Target Protein Families

Intermediate filament family
Target Research Area

Others
Target Synonyms

NEFL; NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein
Target Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Rabbit anti-Human Neurofilament L Polyclonal Antibody

Specifications

Immunogen Information

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