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The antibody against STYX was raised in rabbit using the Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against STYX was raised in rabbit using the Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: MCF-7 whole cell lysate, 293T whole cell lysate, HL60 whole cell lysate | All lanes: STYX antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 26 kDa | Observed band size: 26 kDa
| Cat.No | ADC-00809A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STYX |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WUJ0 |
Uniprot Id
Q8WUJ0
Target Species
Human
Target Name
STYX
Target Full Name
Serine/threonine/tyrosine-interacting protein
Target Function
Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
Target Subcellular Location
Nucleus. Cytoplasm, cytosol.
Target Protein Families
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Target Synonyms
Protein tyrosine phosphatase like protein ; Protein tyrosine phosphatase-like protein; Serine/threonine/tyrosine interacting protein; Serine/threonine/tyrosine-interacting protein; Styx; STYX_HUMAN
Target Background
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes.
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