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The antibody against DYNC1H1 was raised in rabbit using the Recombinant Human Cytoplasmic dynein 1 heavy chain 1 protein (12-66AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against DYNC1H1 was raised in rabbit using the Recombinant Human Cytoplasmic dynein 1 heavy chain 1 protein (12-66AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using DYNC1H1 Antibody at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using DYNC1H1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-12021A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DYNC1H1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cytoplasmic dynein 1 heavy chain 1 protein (12-66AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14204 |
Uniprot Id
Q14204
Target Species
Human
Target Name
DYNC1H1
Target Full Name
Cytoplasmic dynein 1 heavy chain 1
Target Function
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.
Target Involvement
Charcot-Marie-Tooth disease 2O (CMT2O); Mental retardation, autosomal dominant 13 (MRD13); Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1)
Target Subcellular Location
Cytoplasm, cytoskeleton.
Target Protein Families
Dynein heavy chain family
Target Synonyms
DYNC1H1; DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain; cytosolic
Target Background
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.
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