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The antibody against SH3BP5 was raised in rabbit using the Recombinant Human SH3 domain-binding protein 5 protein (49-455AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SH3BP5 was raised in rabbit using the Recombinant Human SH3 domain-binding protein 5 protein (49-455AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using SH3BP5 Antibody at dilution of 1:1002
| Cat.No | ADC-14563A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SH3BP5 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human SH3 domain-binding protein 5 protein (49-455AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60239 |
Uniprot Id
O60239
Target Species
Human
Target Name
SH3BP5
Target Full Name
SH3 domain-binding protein 5
Target Function
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Target Subcellular Location
Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.
Target Protein Families
SH3BP5 family
Target Tissue Specificity
Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
Target Synonyms
3BP5_HUMAN; OTTHUMP00000208289; OTTHUMP00000208291; OTTHUMP00000208294; SAB; SH3 binding protein; SH3 domain binding protein 5 (BTK associated); SH3 domain binding protein 5; SH3 domain binding protein that preferentially associates with BTK; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3 domainbinding protein 5; SH3BP 5; SH3BP-5; Sh3bp5
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