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The antibody against PIF1 was raised in rabbit using the Recombinant Human ATP-dependent DNA helicase PIF1 protein (125-360AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PIF1 was raised in rabbit using the Recombinant Human ATP-dependent DNA helicase PIF1 protein (125-360AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human gastric cancer using PIF1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using PIF1 Antibody at dilution of 1:1002
| Cat.No | ADC-15044A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PIF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human ATP-dependent DNA helicase PIF1 protein (125-360AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H611 |
Uniprot Id
Q9H611
Target Species
Human
Target Name
PIF1
Target Full Name
ATP-dependent DNA helicase PIF1
Target Function
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Target Subcellular Location
Nucleus.; [Isoform 4]: Mitochondrion.
Target Protein Families
Helicase family, PIF1 subfamily
Target Tissue Specificity
Weak ubiquitous expression.
Target Synonyms
ATP dependent DNA helicase PIF1; ATP-dependent DNA helicase PIF1; C15orf20; DNA helicase homolog PIF1; DNA helicase PIF1; DNA repair and recombination helicase PIF1; Petite integration frequency 1; PIF; PIF1 5' to 3' DNA helicase; PIF1 5' to 3' DNA helicase homolog; PIF1; PIF1 DNA helicase; PIF1/RRM3 DNA helicase like protein; PIF1/RRM3 DNA helicase-like protein; PIF1_HUMAN
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