Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against MAML1 was raised in rabbit using the Recombinant Human Mastermind-like protein 1 protein (1-45AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MAML1 was raised in rabbit using the Recombinant Human Mastermind-like protein 1 protein (1-45AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skin tissue using MAML1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using MAML1 Antibody at dilution of 1:1002
| Cat.No | ADC-15150A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAML1 |
| Target Synonyms | Mam-1 antibody; Mam1 antibody; MAML 1 antibody; Maml1 antibody; MAML1_HUMAN antibody; Mastermind like 1 antibody; Mastermind-like protein 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mastermind-like protein 1 protein (1-45AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92585 |
Uniprot Id
Q92585
Target Species
Human
Target Name
MAML1
Target Full Name
Mastermind-like protein 1
Target Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Target Subcellular Location
Nucleus speckle. Note=Nuclear, in a punctate manner.
Target Protein Families
Mastermind family
Target Tissue Specificity
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
Target Synonyms
Mam-1; Mam1; MAML 1; Maml1; MAML1_HUMAN; Mastermind like 1; Mastermind-like protein 1
Target Background
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
