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The antibody against KDM1B was raised in rabbit using the Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against KDM1B was raised in rabbit using the Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using KDM1B Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using KDM1B Antibody at dilution of 1:1002
| Cat.No | ADC-15183A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM1B |
| Target Synonyms | amine oxidase (flavin containing) domain 1 antibody; amine oxidase | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NB78 |
Uniprot Id
Q8NB78
Target Species
Human
Target Name
KDM1B
Target Full Name
Lysine-specific histone demethylase 2
Target Function
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
Target Subcellular Location
Nucleus.
Target Protein Families
Flavin monoamine oxidase family
Target Synonyms
amine oxidase (flavin containing) domain 1 ; amine oxidase, flavin containing 1; AOF1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; FLJ33898; FLJ34109; FLJ43328; KDM1B; KDM1B_HUMAN; LSD2; lysine (K)-specific demethylase 1B ; Lysine-specific demethylase 2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
Target Background
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).
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