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The antibody against NOXA1 was raised in rabbit using the Recombinant Human NADPH oxidase activator 1 protein (150-313AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against NOXA1 was raised in rabbit using the Recombinant Human NADPH oxidase activator 1 protein (150-313AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung cancer using NOXA1 Antibody at dilution of 1:1002
| Cat.No | ADC-15828A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOXA1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NADPH oxidase activator 1 protein (150-313AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86UR1 |
Uniprot Id
Q86UR1
Target Species
Human
Target Name
NOXA1
Target Full Name
NADPH oxidase activator 1
Target Function
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Target Subcellular Location
Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Target Protein Families
NCF2/NOXA1 family
Target Tissue Specificity
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
Target Synonyms
Antigen NY CO 31; Antigen NY-CO-31; FLJ25475; Inhibitory NADPH oxidase activator 1; MGC131800; NADPH oxidase activator 1; NCF2 like protein; NCF2-like protein; NOX activator 1; NOXA 1; Noxa1; NOXA1_HUMAN; NY CO 31; p51 nox; p51-nox; p51NOX; P67phox like factor; P67phox-like factor; SDCCAG31; Serologically defined colon cancer antigen 31
Target Background
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene.
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