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The antibody against ZIC3 was raised in rabbit using the Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ZIC3 was raised in rabbit using the Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using ZIC3 Antibody at dilution of 1:100
| Cat.No | ADC-16490A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZIC3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60481 |
Uniprot Id
O60481
Target Species
Human
Target Name
ZIC3
Target Full Name
Zinc finger protein ZIC 3
Target Function
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Target Involvement
Heterotaxy, visceral, 1, X-linked (HTX1); VACTERL association X-linked with or without hydrocephalus (VACTERLX); Congenital heart defects, multiple types, 1, X-linked (CHTD1)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
GLI C2H2-type zinc-finger protein family
Target Synonyms
Heterotaxy 1; HTX; HTX1; VACTERLX; ZIC 3; Zic family member 3 (odd paired Drosophila homolog heterotaxy 1); Zic family member 3; Zic3; ZIC3_HUMAN; Zinc finger protein 203; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3); Zinc finger protein ZIC 3; ZNF203
Target Background
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
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