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The antibody against CDC45 was raised in rabbit using the Recombinant Human Cell division control protein 45 homolog protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CDC45 was raised in rabbit using the Recombinant Human Cell division control protein 45 homolog protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human testis tissue using CDC45 Antibody at dilution of 1:1002
| Cat.No | ADC-16575A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDC45 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cell division control protein 45 homolog protein (1-270AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75419 |
Uniprot Id
O75419
Target Species
Human
Target Name
CDC45
Target Full Name
Cell division control protein 45 homolog
Target Function
Required for initiation of chromosomal DNA replication.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
CDC45 family
Target Tissue Specificity
Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.
Target Synonyms
CDC 45; CDC 45L; CDC45 (cell division cycle 45; S.cerevisiae homolog) like; CDC45; CDC45 cell division cycle 45 like; CDC45 like; CDC45 related protein; CDC45_HUMAN; CDC45L2; Cell division control protein 45 homolog; Cell division cycle 45 like 2; Cell division cycle 45 like; PORC PI 1; PORC-PI-1
Target Background
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.
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