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The antibody against EFHC1 was raised in rabbit using the Recombinant Human EF-hand domain-containing protein 1 protein (391-640AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against EFHC1 was raised in rabbit using the Recombinant Human EF-hand domain-containing protein 1 protein (391-640AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using EFHC1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using EFHC1 Antibody at dilution of 1:1002
| Cat.No | ADC-16794A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EFHC1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human EF-hand domain-containing protein 1 protein (391-640AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5JVL4 |
Uniprot Id
Q5JVL4
Target Species
Human
Target Name
EFHC1
Target Full Name
EF-hand domain-containing protein 1
Target Function
Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.
Target Involvement
Juvenile myoclonic epilepsy 1 (EJM1); Juvenile absence epilepsy 1 (JAE1)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Target Tissue Specificity
Widely expressed. Not detected in lymphocytes.
Target Synonyms
EF hand domain (C terminal) containing 1 ; EF hand domain containing protein 1; EF-hand domain-containing protein 1; Efhc1; EFHC1_HUMAN; EJA1; EJM1; FLJ10466; FLJ37290; JAE; Myoclonin 1; Myoclonin-1
Target Background
This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy. Alternatively spliced transcript variants have been described.
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