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The antibody against BCO1 was raised in rabbit using the Recombinant Human Beta,beta-carotene 15,15\'-dioxygenase protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against BCO1 was raised in rabbit using the Recombinant Human Beta,beta-carotene 15,15\’-dioxygenase protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human small intestine tissue using BCO1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using BCO1 Antibody at dilution of 1:1002
| Cat.No | ADC-18386A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCO1 |
| Target Synonyms | 15'-monooxygenase 1 antibody; Beta-carotene dioxygenase 1 antibody; FLJ10730 antibody, 15'-monooxygenase antibody; beta-carotene 15, BCDO antibody; BCDO1 antibody; BCDO1_HUMAN antibody; BCMO antibody; Bcmo1 antibody; BCO antibody; BCO1 antibody; Beta, beta-carotene 15 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta,beta-carotene 15,15\'-dioxygenase protein (1-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HAY6 |
Uniprot Id
Q9HAY6
Target Species
Human
Target Name
BCO1
Target Full Name
Beta,beta-carotene 15,15'-dioxygenase
Target Function
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.
Target Involvement
Hypercarotenemia and vitamin A deficiency, autosomal dominant (ADHVAD)
Target Protein Families
Carotenoid oxygenase family
Target Tissue Specificity
Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.
Target Synonyms
BCDO; BCDO1; BCDO1_HUMAN; BCMO; Bcmo1; BCO; BCO1; Beta,beta-carotene 15,15'-monooxygenase; beta-carotene 15,15'-monooxygenase 1; Beta-carotene dioxygenase 1; FLJ10730
Target Background
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta, beta-carotene into two retinal molecules.
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