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The antibody against X was raised in rabbit using the Recombinant Woodchuck hepatitis B virus Protein X protein (1-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against X was raised in rabbit using the Recombinant Woodchuck hepatitis B virus Protein X protein (1-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20679A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | X |
| Target Synonyms | X antibody; Protein X antibody; HBx antibody; Peptide X antibody; pX antibody | Form | Liquid |
| Species Reactivity | Woodchuck hepatitis B virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Woodchuck hepatitis B virus Protein X protein (1-141AA) | Target Species | Woodchuck hepatitis B virus (isolate 8) (WHV) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P17401 |
Uniprot Id
P17401
Target Species
Woodchuck hepatitis B virus
Target Name
X
Target Function
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
Target Subcellular Location
Host cytoplasm. Host nucleus. Host mitochondrion.
Target Protein Families
Orthohepadnavirus protein X family
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