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The antibody against lasA was raised in rabbit using the Recombinant Pseudomonas aeruginosa Protease LasA protein (237-418AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against lasA was raised in rabbit using the Recombinant Pseudomonas aeruginosa Protease LasA protein (237-418AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-20694A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | lasA |
| Target Synonyms | lasA antibody; PA1871Protease LasA antibody; EC 3.4.24.- antibody; Staphylolytic protease antibody | Form | Liquid |
| Species Reactivity | Pseudomonas aeruginosa | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Pseudomonas aeruginosa Protease LasA protein (237-418AA) | Target Species | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14789 |
Uniprot Id
P14789
Target Species
Pseudomonas aeruginosa
Target Name
LASA
Target Function
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate.
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase M23A family
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