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The antibody against WBP2 was raised in rabbit using the Recombinant Human WW domain-binding protein 2 protein (1-261AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against WBP2 was raised in rabbit using the Recombinant Human WW domain-binding protein 2 protein (1-261AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using WBP2 Antibody at dilution of 1:100
| Cat.No | ADC-22984A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WBP2 |
| Target Synonyms | MGC18269 antibody; WBP 2 antibody; WBP-2 antibody; Wbp2 antibody; WBP2_HUMAN antibody; WW domain binding protein 2 antibody; WW domain-binding protein 2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human WW domain-binding protein 2 protein (1-261AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q969T9 |
Uniprot Id
Q969T9
Target Species
Human
Target Name
WBP2
Target Full Name
WW domain-binding protein 2
Target Function
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.
Target Involvement
Deafness, autosomal recessive, 107 (DFNB107)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
MGC18269; WBP 2; WBP-2; Wbp2; WBP2_HUMAN; WW domain binding protein 2; WW domain-binding protein 2
Target Background
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment.
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