Rabbit anti-Human TCHH Polyclonal Antibody

Uniprot Id

Q07283

Target Species

Human

Target Name

TCHH

Target Full Name

Trichohyalin

Target Function

Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.

Target Involvement

Uncombable hair syndrome 3 (UHS3)

Target Protein Families

S100-fused protein family

Target Tissue Specificity

Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium.

Target Research Area

Others

Target Synonyms

220K trichohyalin granular protein; Hair follicle protein AHF; MGC157889; MGC157890; RP11-107M16.3; TCHH; THH; THL; TRHY_HUMAN; Trichohyalin; Trichohyalin granular protein

Target Background

The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome.