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The antibody against LRRC8E was raised in rabbit using the Recombinant Human Volume-regulated anion channel subunit LRRC8E protein (353-630AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against LRRC8E was raised in rabbit using the Recombinant Human Volume-regulated anion channel subunit LRRC8E protein (353-630AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human gastric cancer using LRRC8E Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using LRRC8E Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using LRRC8E Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-24536A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LRRC8E |
| Target Synonyms | LRRC8E; Volume-regulated anion channel subunit LRRC8E; Leucine-rich repeat-containing protein 8E | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Volume-regulated anion channel subunit LRRC8E protein (353-630AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6NSJ5 |
Uniprot Id
Q6NSJ5
Target Species
Human
Target Name
LRRC8E
Target Full Name
Volume-regulated anion channel subunit LRRC8E
Target Function
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
LRRC8 family
Target Synonyms
LRRC8E; Volume-regulated anion channel subunit LRRC8E; Leucine-rich repeat-containing protein 8E
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