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The antibody against OTOP1 was raised in rabbit using the Recombinant Human Proton channel OTOP1 protein (414-544AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against OTOP1 was raised in rabbit using the Recombinant Human Proton channel OTOP1 protein (414-544AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
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| Cat.No | ADC-04000A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OTOP1 |
| Target Synonyms | OTOP1 antibody; Proton channel OTOP1 antibody; Otopetrin-1 antibody; hOtop1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Proton channel OTOP1 protein (414-544AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7RTM1 |
Uniprot Id
Q7RTM1
Target Species
Human
Target Name
OTOP1
Target Full Name
Proton channel OTOP1
Target Function
Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Otopetrin family
Target Synonyms
OTOP1; Proton channel OTOP1; Otopetrin-1; hOtop1
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