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The antibody against CASP7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Caspase-7 p20. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against CASP7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Caspase-7 p20. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of Jurkat cells using Cleaved-Caspase-7 p20 (D198) Polyclonal Antibody
| Cat.No | ADC-39968A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CASP7 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Caspase-7 p20. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55210 |
Uniprot Id
P55210
Target Species
Human
Target Name
CASP7
Target Full Name
Caspase-7
Target Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9.; Lacks enzymatic activity.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Peptidase C14A family
Target Tissue Specificity
Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Target Research Area
Apoptosis
Target Synonyms
apoptosis-related cysteine peptidase; Apoptotic protease Mch-3; CASP-7; CASP7; CASP7_HUMAN; Caspase-7 subunit p11; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3
Target Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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