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The antibody against ATAD3B was raised in rabbit using the Recombinant Human ATPase family AAA domain-containing protein 3B protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against ATAD3B was raised in rabbit using the Recombinant Human ATPase family AAA domain-containing protein 3B protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using ATAD3B Antibody at dilution of 1:1002
| Cat.No | ADC-40216A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATAD3B |
| Target Synonyms | ATAD3B antibody; KIAA1273 antibody; TOB3 antibody; ATPase family AAA domain-containing protein 3B antibody; AAA-TOB3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human ATPase family AAA domain-containing protein 3B protein (1-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5T9A4 |
Uniprot Id
Q5T9A4
Target Species
Human
Target Name
ATAD3B
Target Full Name
ATPase family AAA domain-containing protein 3B
Target Function
May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein.
Target Protein Families
AAA ATPase family
Target Tissue Specificity
Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).
Target Synonyms
ATAD3B; KIAA1273; TOB3; ATPase family AAA domain-containing protein 3B; AAA-TOB3
Target Background
The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene.
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