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The antibody against HARS was raised in rabbit using the Synthesized peptide derived from C-terminal of Human HARS. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against HARS was raised in rabbit using the Synthesized peptide derived from C-terminal of Human HARS. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Western blot analysis of extracts from HeLa cells, using HARS antibody.
Immunofluorescence analysis of HepG2 ells, using HARS antibody.2
| Cat.No | ADC-42151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HARS |
| Target Synonyms | cytoplasmic antibody; EC 6.1.1.21 antibody; FLJ20491 antibody; HARS antibody; HisRS antibody; Histidine tRNA ligase | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human HARS. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P12081 |
Uniprot Id
P12081
Target Species
Human
Target Name
HARS1
Target Full Name
Histidine--tRNA ligase, cytoplasmic
Target Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Target Involvement
Usher syndrome 3B (USH3B); Charcot-Marie-Tooth disease 2W (CMT2W)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-II aminoacyl-tRNA synthetase family
Target Tissue Specificity
Brain, heart, liver and kidney.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
cytoplasmic; EC 6.1.1.21 ; FLJ20491 ; HARS; HisRS; Histidine tRNA ligase, cytoplasmic; histidine translase; Histidine tRNA ligase; Histidine--tRNA ligase; Histidyl tRNA synthetase ; Histidyl-tRNA synthetase; HRS ; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; SYHC_HUMAN; USH3B
Target Background
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.
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