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The antibody against SUCLG1 was raised in rabbit using the Recombinant Human Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial protein (210-316AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SUCLG1 was raised in rabbit using the Recombinant Human Succinate–CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial protein (210-316AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-05019A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SUCLG1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial protein (210-316AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P53597 |
Uniprot Id
P53597
Target Species
Human
Target Name
SUCLG1
Target Full Name
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Target Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Target Involvement
Mitochondrial DNA depletion syndrome 9 (MTDPS9)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Succinate/malate CoA ligase alpha subunit family
Target Synonyms
FLJ21114; FLJ43513; GALPHA; MTDPS9; SCS alpha; SCS-alpha; SUCA_HUMAN; Succinate CoA ligase alpha subunit ; Succinyl CoA ligase [GDP forming] subunit alpha mitochondrial; Succinyl CoA synthetase subunit alpha; Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha; mitochondrial; Succinyl-CoA synthetase subunit alpha; SUCLA1; SUCLG 1; SUCLG1
Target Background
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion.
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