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The antibody against PHF6 was raised in rabbit using the Recombinant Human PHD finger protein 6 protein (2-312AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, IP.
The antibody against PHF6 was raised in rabbit using the Recombinant Human PHD finger protein 6 protein (2-312AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, IP.
$299.00
| Cat.No | ADC-44805A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHF6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB, IP | Storage | Upon receipt |
| Immunogen Description | Recombinant Human PHD finger protein 6 protein (2-312AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IWS0 |
Uniprot Id
Q8IWS0
Target Species
Human
Target Name
PHF6
Target Full Name
PHD finger protein 6
Target Function
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
Target Involvement
Boerjeson-Forssman-Lehmann syndrome (BFLS)
Target Subcellular Location
Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore. Note=Nuclear, it particularly localizes to the nucleolus.
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
AC004383.6; BFLS; BORJ; CENP 31; Centromere protein 31; MGC14797; OTTHUMP00000024063; PHD finger protein 6; PHD like zinc finger protein; PHD-like zinc finger protein; Phf6; PHF6_HUMAN
Target Background
This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.
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