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The antibody against SHOC2 was raised in rabbit using the Human SHOC2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against SHOC2 was raised in rabbit using the Human SHOC2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-47184A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SHOC2 |
| Target Synonyms | KIAA0862 antibody; Leucine-rich repeat protein SHOC-2 antibody; Protein soc-2 homolog antibody; Protein Sur-8 homolog antibody; Ras-binding protein Sur-8 antibody; SHOC2 antibody; SHOC2_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human SHOC2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UQ13 |
Uniprot Id
Q9UQ13
Target Species
Human
Target Name
SHOC2
Target Full Name
Leucine-rich repeat protein SHOC-2
Target Function
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Target Involvement
Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
SHOC2 family
Target Synonyms
KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein Sur-8 homolog; Ras-binding protein Sur-8; SHOC2; SHOC2_HUMAN
Target Background
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
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