Rabbit anti-Human HEY1 Polyclonal Antibody

Uniprot Id

Q9Y5J3

Target Species

Human

Target Name

HEY1

Target Full Name

Hairy/enhancer-of-split related with YRPW motif protein 1

Target Function

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Involved in the regulation of liver cancer cells self-renewal.

Target Subcellular Location

Nucleus.

Target Protein Families

HEY family

Target Tissue Specificity

Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

Target Synonyms

Basic helix loop helix protein OAF1; bHLHb31; Cardiovascular helix loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF-2; CHF2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split related protein 1; Hairy and enhancer of split-related protein 1; Hairy enhancer-of-split related with YRPW motif protein 1; Hairy related transcription factor 1; Hairy-related transcription factor 1; Hairy/enhancer of split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; HERP2; HES related repressor protein 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HESR1; HEY 1; hey1; HEY1_HUMAN; hHRT1; HRT-1; HRT1; OAF1

Target Background

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.