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The antibody against HADH was raised in rabbit using the Human HADH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against HADH was raised in rabbit using the Human HADH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-53158A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HADH |
| Target Synonyms | 3 hydroxyacyl Coenzyme A dehydrogenase antibody; HAD antibody; HADH antibody; HADH1 antibody; HADHSC antibody; HADHSC, formerly antibody; HADSC, formerly antibody; HCDH antibody; HCDH_HUMAN antibody; HHF4 antibody; Hydroxyacyl CoA dehydrogenase antibody; Hydroxyacyl-coenzyme A dehydrogenase antibody; hydroxyacyl-coenzyme A dehydrogenase, formerly antibody; Short chain 3 hydroxyacyl CoA dehydrogenase mitochondrial antibody; short chain 3-hydroxyacyl-coa dehydrogenase antibody; Short-chain 3-hydroxyacyl-CoA dehydrogenase antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human HADH | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q16836 |
Uniprot Id
Q16836
Target Species
Human
Target Name
HADH
Target Full Name
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Target Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion.
Target Involvement
3-alpha-hydroxyacyl-CoA dehydrogenase deficiency (HADH deficiency); Familial hyperinsulinemic hypoglycemia 4 (HHF4)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
3-hydroxyacyl-CoA dehydrogenase family
Target Tissue Specificity
Expressed in liver, kidney, pancreas, heart and skeletal muscle.
Target Synonyms
3 hydroxyacyl Coenzyme A dehydrogenase; HAD; HADH; HADH1; HADHSC; HADHSC, formerly; HADSC, formerly; HCDH; HCDH_HUMAN; HHF4; Hydroxyacyl CoA dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; L 3 hydroxyacyl Coenzyme A dehydrogenase short chain; M SCHAD; Medium and short chain L 3 hydroxyacyl coenzyme A dehydrogenase ; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; MGC8392; mitochondrial; MSCHAD; OTTHUMP00000162626; OTTHUMP00000219688; SCHAD; SCHAD, formerly; Short chain 3 hydroxyacyl CoA dehydrogenase mitochondrial; short chain 3-hydroxyacyl-coa dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase
Target Background
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.
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