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The antibody against GRPR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GRPR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04232A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GRPR |
| Target Synonyms | BB2; BB2R; BRS2; GRPR | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, A-549, MCF7, Mouse brain, Mouse pancreas, SGC-7901, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | KNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV | Uniprot ID | P30550 |
Uniprot Id
P30550
Target Species
Human
Target Name
GRPR
Target Full Name
Gastrin-releasing peptide receptor
Target Function
Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.
Target Research Area
Neuroscience
Target Synonyms
BB2; Bombesin BB2 receptor; bombesin receptor 2; Gastrin Releasing Peptide Receptor; Gastrin-releasing peptide receptor; GRP preferring bombesin receptor; GRP R; GRP-preferring bombesin receptor; GRP-R; Grp/bombesin receptor; Grpr; GRPR_HUMAN
Target Background
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
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