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The antibody against OASL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human OASL (NP_003724.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against OASL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human OASL (NP_003724.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using OASL Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Negative control (NC):Hep G2
Exposure time: 0.8s.
| Cat.No | ADA-08256A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OASL |
| Target Synonyms | OASL; OASLd; TRIP-14; TRIP14; p59 OASL; p59-OASL; p59OASL; 2'-5'-oligoadenylate synthetase like | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HCT 116, U-87 MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human OASL (NP_003724.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15646 | Immunogen Sequence |
Uniprot Id
Q15646
Target Species
Human
Target Name
OASL
Target Full Name
2'-5'-oligoadenylate synthase-like protein
Target Function
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Target Subcellular Location
[Isoform p56]: Nucleus, nucleolus. Cytoplasm.; [Isoform p30]: Cytoplasm.
Target Protein Families
2-5A synthase family
Target Tissue Specificity
Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
Target Research Area
Cell Biology
Target Synonyms
2' 5' oligoadenylate synthetase like; 2''-5''-OAS-related protein; 2''-5''-OAS-RP; 2''-5''-oligoadenylate synthase-like protein; 2'-5' oligoadenylate synthetase-like 2; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2' 5' oligoadenylate synthetase like protein; 59 kDa 2''-5''-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; M1204; Mmu-OASL; OASL; OASL_HUMAN; Oasl2; p59 OASL; p59OASL; THYROID HORMONE RECEPTOR INTERACTOR 14; Thyroid receptor interacting protein 14; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14
Target Background
Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm.
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