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The antibody against ptxA was raised in rabbit using the Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against ptxA was raised in rabbit using the Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-50566A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ptxA |
| Form | Liquid | Species Reactivity | Bordetella pertussis |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA) | Target Species | Bordetella pertussis |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04977 |
Uniprot Id
P04977
Target Species
Bordetella pertussis
Target Name
PTXA
Target Function
S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
Target Subcellular Location
Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.
Target Protein Families
Bacterial exotoxin subunit A family
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