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The antibody against AASS was raised in rabbit using the Recombinant Human Alpha-aminoadipic semialdehyde synthase, mitochondrial protein (224-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against AASS was raised in rabbit using the Recombinant Human Alpha-aminoadipic semialdehyde synthase, mitochondrial protein (224-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-04579A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AASS |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Alpha-aminoadipic semialdehyde synthase, mitochondrial protein (224-364AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UDR5 |
Uniprot Id
Q9UDR5
Target Species
Human
Target Name
AASS
Target Full Name
Alpha-aminoadipic semialdehyde synthase, mitochondrial
Target Function
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
Target Involvement
Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
Target Subcellular Location
Mitochondrion.
Target Protein Families
AlaDH/PNT family; Saccharopine dehydrogenase family
Target Tissue Specificity
Expressed in all 16 tissues examined with highest expression in the liver.
Target Synonyms
AASSAlpha-aminoadipic semialdehyde synthase; mitochondrial; LKR/SDH) [Includes: Lysine ketoglutarate reductase; LKR; LOR; EC 1.5.1.8); Saccharopine dehydrogenase; SDH; EC 1.5.1.9)]
Target Background
This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
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