Rabbit anti-Human ABCB6 Polyclonal Antibody

Uniprot Id

Q9NP58

Target Species

Human

Target Name

ABCB6

Target Full Name

ATP-binding cassette sub-family B member 6

Target Function

ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis.

Target Involvement

Microphthalmia, isolated, with coloboma, 7 (MCOPCB7); Dyschromatosis universalis hereditaria 3 (DUH3); Pseudohyperkalemia, familial, 2, due to red cell leak (PSHK2)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane. Late endosome membrane. Early endosome membrane. Secreted, extracellular exosome. Mitochondrion. Endosome, multivesicular body membrane. Melanosome membrane.

Target Protein Families

ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3.A.1.210) subfamily

Target Tissue Specificity

Widely expressed. High expression is detected in the retinal epithelium. Expressed in mature erythrocytes.

Target Synonyms

ABC; ABC transporter umat ; ABC14; Abcb6; ABCB6_HUMAN; ATP binding cassette sub family B member 6; mitochondrial precursor ; ATP binding cassette; sub family B (MDR/TAP); member 6; ATP-binding cassette half-transporter; ATP-binding cassette sub-family B member 6; ATP-binding cassette sub-family B member 6; mitochondrial; DUH3; LAN; MCOPCB7; Mitochondrial ABC transporter 3; mitochondrial; Mt ABC transporter 3; Mt-ABC transporter 3; MTABC3; P glycoprotein related protein ; P-glycoprotein-related protein; PRP; Ubiquitously expressed mammalian ABC half transporter; Ubiquitously-expressed mammalian ABC half transporter; UMAT