Rabbit anti-Human ABCC6 Polyclonal Antibody

Uniprot Id

O95255

Target Species

Human

Target Name

ABCC6

Target Full Name

ATP-binding cassette sub-family C member 6

Target Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin.; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.; Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.

Target Involvement

Pseudoxanthoma elasticum (PXE); Arterial calcification of infancy, generalized, 2 (GACI2)

Target Subcellular Location

[Isoform 1]: Basolateral cell membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein.

Target Protein Families

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Target Tissue Specificity

Expressed in kidney and liver. Very low expression in other tissues.

Target Synonyms

ABC34; Abcc6; Anthracycline resistance-associated protein; ARA; ATP binding cassette sub family C (CFTR/MRP) member 6; ATP binding cassette sub family C member 6; ATP-binding cassette sub-family C member 6; EST349056; GACI2; MLP1; MOAT E; MOAT-E; MOATE; MRP 6; MRP6; MRP6_HUMAN; Multi-specific organic anion transporter E; Multidrug resistance associated protein 6; Multidrug resistance-associated protein 6; Multidrug resistance-associated protein 6, URG7 protein; multispecific organic anion transporter E; PXE; PXE1; URG7; URG7 protein

Target Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.