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The antibody against ADD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ADD1 (NP_054908.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ADD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ADD1 (NP_054908.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04744A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADD1 |
| Target Synonyms | ADDA; ADD1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BT-474, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ADD1 (NP_054908.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P35611 | Immunogen Sequence |
Uniprot Id
P35611
Target Species
Human
Target Name
ADD1
Target Full Name
Alpha-adducin
Target Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Aldolase class II family, Adducin subfamily
Target Tissue Specificity
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Target Synonyms
ADD A; ADD1; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; MGC3339; MGC44427; OTTHUMP00000151163; OTTHUMP00000151164; OTTHUMP00000151165; OTTHUMP00000218664; OTTHUMP00000218665
Target Background
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C.
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